Protein-free Medium Gauges Demand to Overcome Challenges in COVID-19 Vaccine Production
With many around the world affected by the COVID-19, pharmaceutical companies are boosting their production capabilities to develop vaccines. Such trends are creating revenue opportunities for players in the serum-free media market. Lonza Group - a Swiss multinational chemicals and biotechnology company, is gaining recognition for its ProVeroTM1 Serum-free Medium, which is of non-animal origin and supports vaccine production.
Companies in the serum-free media market are taking cues from such innovations and increasing the availability of protein-free medium, which is optimized for fast cell proliferation. They are developing several serum-free media (SFM) options that help to reduce production variables for vaccine production. In order to avoid any challenges during the downstream processing of recombinant protein or vaccine production, manufacturers are opting for protein-free medium.
Low Levels of Human Recombinant Insulin in Media Facilitates Downstream Processing
The global serum-free media market is projected to reach US$ 660.4 Mn by 2031. Manufacturers are increasing their output capacities in customized cell culture media. Thermo Fisher Scientific - the U.S. provisioner of scientific instrumentation, reagents & consumables, and software services, is publicizing its Gibco serum-free media, which promotes superior cell growth and viability.
Manufacturers in the serum-free media market are developing medium that enable precise evaluations of cellular function and facilitate consistent performance. Enhanced detection of cellular mediators and for better control over physiological responsiveness is preferred in serum-free media. The absence of proteins and only very low levels of human recombinant insulin facilitate both downstream processing and regulatory compliance.
Key Components of SFM Optimized to Develop Recombinant Therapeutic Proteins
The increasing demand for recombinant protein products is fueling the production of serum-free media. The serum-free media market is expected to advance at a favorable CAGR of 7% during the forecast tenure. Different media contain different formulations that have the potential to adapt to the growth of different cell lines and the production of recombinant protein.
Based on the characteristics of Chinese hamster ovary (CHO) cells and its advantages in recombinant therapeutic protein (RTP) production, key components of SFM are being optimized to different degrees and proportions. The Plackett Burman method (PBM) and the response surface method are routinely used for SFM optimization and can be combined with other statistical methods such as non-parametric Gaussian kernel regression.
FBS-free Medium Eliminates Possibility of Lot Variations in MSCs During Manufacture
Mesenchymal Stem/Stromal Cells (MSCs) hold promising potentials for treating a variety of conditions in veterinary medicine. MSCs are isolated and expanded invitro in a medium that is supplemented with fetal bovine serum (FBS). However, the use of FBS as a medium component during manufacturing may pose several issues. Since FBS can be a source of unwanted pathogens, companies in the serum-free media market are partnering with researchers to develop FBS-free medium that supports both isolation and expansion of MSCs from canine adipose tissue, while removing unwanted pathogens, immune response, and lot-to-lot variations.
Serum-free Hybridoma Helps Prevent Contamination of Cell Culture Facilities
Companies in the serum-free media market are boosting the production of hybridoma media. Leinco Technologies - a biotechnology company in Fenton, Missouri, is gaining popularity for its AlphaGrow Serum Free Hybridoma that offers better lot-to-lot consistency in applications. Increased antibody production and low cost attributes of serum-free hybridoma are being preferred by researchers and scientists.
The inconveniences of serum include the need to screen lots and is subject to variability in cost & quality. Companies are capitalizing on this opportunity, since the presence of contaminating bovine IgG creates issues for researchers. Such findings are triggering the demand for serum-free hybridoma media, as animal-derived ingredients carry the risk of introducing adventitious agents such as viruses and prions that can contaminate cell culture facilities.
Serum-free Cell Culturing Gaining Prominence in Biological Facilities
Apart from CHO cell media and protein expression media, companies in the serum-free media market are increasing their focus on human microglial cell culture serum-free media. On the other hand, serum-free cell culturing is gaining recognition in biological facilities. Researchers in cell biology are familiar with adding bovine or calf serum to cell cultures. Unfortunately, adding serum means adding a highly variable and non-standardized product to a well ordered system. Hence, manufacturers are leveraging this opportunity to boost product innovations.
Companies are increasing the availability of chemically defined serum-free media. Serum-free cell culturing is gaining market prominence, since objections have been raised to the use of serum in cell culture on regulatory and ethical grounds.
Analysts’ Viewpoint
Media formulations without FBS are essential for COVID-19 vaccine production and has led to the popularity of protein-free medium. Since FBS is associated with inconsistencies between batches of MSCs, companies in the serum-free media market should develop FBS-free medium that supports both isolation and expansion of MSCs from canine adipose tissue, while removing unwanted pathogens, immune response, and lot-to-lot variations.
Serum-free hybridoma media ensures consistent downstream purification results. This medium eliminates ethical concerns surrounding the collection of FBS. MSCs cultivated in FBS-free media exhibits a more uniform size and shorter population doubling time as compared to the FBS medium. Manufacturers are boosting credibility credentials by minimizing waste in labs by adopting bottles that utilize less source material than comparable media bottles on the market.
Serum-free Media Market: Overview
Easier Downstream Processing of Products Post Production from Media
Increase in Demand for Various Recombinant Proteins and Types of Culture
Continuous Research & Development for Development of Novel Therapeutic Drugs
Serum-free Media Market: Competition Landscape
Serum-free Media Market Snapshot
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Attribute |
Detail |
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Market Size Value in 2020 (Base Year) |
US$ 320 Mn |
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Market Forecast Value in 2031 |
US$ 660.4 Mn |
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Growth Rate (CAGR) |
7% |
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Forecast Period |
2021–2031 |
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Quantitative Units |
US$ Mn for Value & ‘000 Units for Volume |
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Market Analysis |
It includes cross segment analysis at global as well as regional level. Moreover, qualitative analysis includes drivers, restraints, opportunities, key trends, and key product/brand analysis. |
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Competition Landscape |
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Format |
Electronic (PDF) + Excel |
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Market Segmentation |
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Regions Covered |
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Countries Covered |
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Companies Profiled |
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Customization Scope |
Available upon request |
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Pricing |
Available upon request |
Serum-free Media Market – Segmentation
| Media Type |
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| End-user |
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| Region |
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Serum-free media market is projected to reach US$ 660.4 Mn by 2031
Serum-free media market is expected to advance at a favorable CAGR of 7% during 2021-2031
Serum-free media market is driven by increase in demand for various recombinant proteins & types of culture
North America accounted for a major share of the global serum-free media market
Key players operating in the global serum-free media market include Thermo Fisher Scientific, Athena Environmental Sciences, Pan Biotech, Bichrom, Irvine Scientific
1. Preface
1.1. Market Definition and Scope
1.2. Market Segmentation
1.3. Key Research Objectives
1.4. Research Highlights
2. Assumptions and Research Methodology
3. Executive Summary: Global Serum-free Media Market
4. Market Overview
4.1. Introduction
4.1.1. Media type Definition
4.1.2. Industry Evolution / Developments
4.2. Overview
4.3. Market Dynamics
4.3.1. Drivers
4.3.2. Restraints
4.3.3. Opportunities
4.4. Global Serum-free Media Market Analysis and Forecast, 2018–2030
4.4.1. Market Revenue Projections (US$ Mn)
4.4.2. Market Volume/Unit Shipments Projections
5. Key Insights
5.1. Key Product/brand Analysis
5.2. Applications of different Serum-free Media’s in Cell culture
5.3. COVID-19 Pandemic Impact on Serum-free Media Market
6. Global Serum-free Media Market Analysis and Forecast, by Media Type
6.1. Introduction & Definition
6.2. Key Findings / Developments
6.3. Market Value Forecast, by Media Type, 2017-2031
6.3.1. CHO Cell Media
6.3.2. Protein Expression Media
6.3.3. Immunology Media
6.3.4. Insect Cell Media
6.3.5. Hybridoma Media
6.3.6. Stem Cell Media
6.3.7. Chemically-defined Media
6.4. Market Attractiveness Analysis, by Media Type
7. Global Serum-free Media Market Analysis and Forecasts, By End-user
7.1. Introduction & Definition
7.2. Key Findings / Developments
7.3. Market Value Forecast, by End-user, 2017–2031
7.3.1. Biopharma Industry
7.3.2. Clinical Research Organizations
7.3.3. Research Centers
7.3.4. Others
7.4. Market Attractiveness Analysis, by End-user
8. Global Serum-free Media Market Analysis and Forecasts, By Region
8.1. Key Findings
8.2. Market Value Forecast, by Region
8.2.1. North America
8.2.2. Europe
8.2.3. Asia Pacific
8.2.4. Latin America
8.2.5. Middle East & Africa
8.3. Market Attractiveness Analysis, by Region
9. North America Serum-free Media Market Analysis and Forecast
9.1. Introduction
9.1.1. Key Findings
9.2. Market Value Forecast, by Media Type, 2017–2031
9.2.1. CHO Cell Media
9.2.2. Protein Expression Media
9.2.3. Immunology Media
9.2.4. Insect Cell Media
9.2.5. Hybridoma Media
9.2.6. Stem Cell Media
9.2.7. Chemically-defined Media
9.3. Market Value Forecast, by End-user, 2017–2031
9.3.1. Biopharma Industry
9.3.2. Clinical Research Organizations
9.3.3. Research Centers
9.3.4. Others
9.4. Market Value Forecast, by Country, 2017–2031
9.4.1. U.S.
9.4.2. Canada
9.5. Market Attractiveness Analysis
9.5.1. By Media Type
9.5.2. By End-user
9.5.3. By Country
10. Europe Serum-free Media Market Analysis and Forecast
10.1. Introduction
10.1.1. Key Findings
10.2. Market Value Forecast, by Media Type, 2017–2031
10.2.1. CHO Cell Media
10.2.2. Protein Expression Media
10.2.3. Immunology Media
10.2.4. Insect Cell Media
10.2.5. Hybridoma Media
10.2.6. Stem Cell Media
10.2.7. Chemically-defined Media
10.3. Market Value Forecast, by End-user, 2017–2031
10.3.1. Biopharma Industry
10.3.2. Clinical Research Organizations
10.3.3. Research Centers
10.3.4. Others
10.4. Market Value Forecast, by Country/Sub-region, 2017–2031
10.4.1. Germany
10.4.2. U.K.
10.4.3. France
10.4.4. Spain
10.4.5. Italy
10.4.6. Rest of Europe
10.5. Market Attractiveness Analysis
10.5.1. By Media Type
10.5.2. By End-user
10.5.3. By Country/Sub-region
11. Asia Pacific Serum-free Media Market Analysis and Forecast
11.1. Introduction
11.1.1. Key Findings
11.2. Market Value Forecast, by Media Type, 2017–2031
11.2.1. CHO Cell Media
11.2.2. Protein Expression Media
11.2.3. Immunology Media
11.2.4. Insect Cell Media
11.2.5. Hybridoma Media
11.2.6. Stem Cell Media
11.2.7. Chemically-defined Media
11.3. Market Value Forecast, by End-user, 2017–2031
11.3.1. Biopharma Industry
11.3.2. Clinical Research Organizations
11.3.3. Research Centers
11.3.4. Others
11.4. Market Value Forecast, by Country/Sub-region, 2017–2031
11.4.1. China
11.4.2. Japan
11.4.3. India
11.4.4. Australia & New Zealand
11.4.5. Rest of Asia Pacific
11.5. Market Attractiveness Analysis
11.5.1. By Media Type
11.5.2. By End-user
11.5.3. By Country/Sub-region
12. Latin America Serum-free Media Market Analysis and Forecast
12.1. Introduction
12.1.1. Key Findings
12.2. Market Value Forecast, by Media Type, 2017–2031
12.2.1. CHO Cell Media
12.2.2. Protein Expression Media
12.2.3. Immunology Media
12.2.4. Insect Cell Media
12.2.5. Hybridoma Media
12.2.6. Stem Cell Media
12.2.7. Chemically-defined Media
12.3. Market Value Forecast, by End-user, 2017–2031
12.3.1. Biopharma Industry
12.3.2. Clinical Research Organizations
12.3.3. Research Centers
12.3.4. Others
12.4. Market Value Forecast, by Country/Sub-region, 2017–2031
12.4.1. Brazil
12.4.2. Mexico
12.4.3. Rest of Latin America
12.5. Market Attractiveness Analysis
12.5.1. By Media Type
12.5.2. By End-user
12.5.3. By Country/Sub-region
13. Middle East & Africa Serum-free Media Market Analysis and Forecast
13.1. Introduction
13.1.1. Key Findings
13.2. Market Value Forecast, by Media Type, 2017–2031
13.2.1. CHO Cell Media
13.2.2. Protein Expression Media
13.2.3. Immunology Media
13.2.4. Insect Cell Media
13.2.5. Hybridoma Media
13.2.6. Stem Cell Media
13.2.7. Chemically-defined Media
13.3. Market Value Forecast, by End-user, 2017–2031
13.3.1. Biopharma Industry
13.3.2. Clinical Research Organizations
13.3.3. Research Centers
13.3.4. Others
13.4. Market Value Forecast, by Country/Sub-region, 2017–2031
13.4.1. GCC Countries
13.4.2. South Africa
13.4.3. Rest of Middle East & Africa
13.5. Market Attractiveness Analysis
13.5.1. By Media Type
13.5.2. By End-user
13.5.3. By Country/Sub-region
14. Competition Landscape
14.1. Market Player – Competition Matrix (By Tier and Size of companies)
14.2. Market Share Analysis by Company (2020)
14.3. Company Profiles
14.3.1. Thermo Fisher Scientific
14.3.1.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.1.2. Product Portfolio
14.3.1.3. SWOT Analysis
14.3.1.4. Strategic Overview
14.3.2. Athena Environmental Sciences
14.3.2.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.2.2. Product Portfolio
14.3.2.3. SWOT Analysis
14.3.2.4. Strategic Overview
14.3.3. Pan Biotech
14.3.3.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.3.2. Product Portfolio
14.3.3.3. SWOT Analysis
14.3.3.4. Strategic Overview
14.3.4. Sigma-Aldrich
14.3.4.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.4.2. Product Portfolio
14.3.4.3. SWOT Analysis
14.3.4.4. Strategic Overview
14.3.5. CellGenix
14.3.5.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.5.2. Product Portfolio
14.3.5.3. SWOT Analysis
14.3.5.4. Strategic Overview
14.3.6. HiMedia Laboratories
14.3.6.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.6.2. Product Portfolio
14.3.6.3. SWOT Analysis
14.3.6.4. Strategic Overview
14.3.7. Biological Industries
14.3.7.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.7.2. Product Portfolio
14.3.7.3. SWOT Analysis
14.3.7.4. Strategic Overview
14.3.8. Irvine Scientific
14.3.8.1. Company Overview (HQ, Business Segments, Employee Strength)
14.3.8.2. Product Portfolio
14.3.8.3. SWOT Analysis
14.3.8.4. Strategic Overview
List of Tables
Table 01: Global Serum-free Media Market Value (US$ Mn) Forecast, by Media Type, 2017–2031
Table 02: Global Serum-free Media Market Value (US$ Mn) Forecast, by End-user, 2017-2031
Table 03: Global Serum-free Media Market Value (US$ Mn) Forecast, by Region, 2017-2031
Table 04: North America Serum-free Media Market Value (US$ Mn) Forecast, by Countries, 2017–2031
Table 05: North America Serum-free Media Market Value (US$ Mn) Forecast, by Media Type, 2017–2031
Table 06: North America Serum-free Media Market Value (US$ Mn) Forecast, by End-user, 2017–2031
Table 07: Europe Serum-free Media Market Value (US$ Mn) Forecast, by Countries/Sub-region, 2017-2031
Table 08: Europe Serum-free Media Market Value (US$ Mn) Forecast, by Media Type, 2017-2031
Table 09: Europe Serum-free Media Market Value (US$ Mn) Forecast, by End-user, 2017-2031
Table 10: Asia Pacific Serum-free Media Market Value (US$ Mn) Forecast, by Countries/Sub-region, 2017-2031
Table 11: Asia Pacific Serum-free Media Market Value (US$ Mn) Forecast, by Media Type, 2017-2031
Table 12: Asia Pacific Serum-free Media Market Value (US$ Mn) Forecast, by End-user, 2017-2031
Table 13: Latin America Serum-free Media Market Value (US$ Mn) Forecast, by Countries/Sub-region, 2017-2031
Table 14: Latin America Serum-free Media Market Value (US$ Mn) Forecast, by Media Type, 2017-2031
Table 15: Latin America Serum-free Media Market Value (US$ Mn) Forecast, by End-user, 2017-2031
Table 16: Middle East & Africa Serum-free Media Market Value (US$ Mn) Forecast, by Countries/Sub-region, 2017-2031
Table 17: Middle East & Africa Serum-free Media Market Value (US$ Mn) Forecast, by Media Type, 2017-2031
Table 18: Middle East & Africa Serum-free Media Market Value (US$ Mn) Forecast, by End-user, 2017-2031
List of Figures
Figure 01: Global Serum-free Media Market Value (US$ Mn) Forecast, 2017-2031
Figure 02: Global Serum-free Media Market Value Share, by Media Type, 2020
Figure 03: Global Serum-free Media Market Value Share, by End-user, 2020
Figure 04: Global Serum-free Media Market Value Share, by Region, 2020
Figure 05: Global Serum-free Media Market Value Share Analysis, by Media Type, 2020 and 2031
Figure 06: Global Serum-free Media Market Attractiveness Analysis, by Media Type, 2021–2031
Figure 07: Global Serum-free Media Market Revenue (US$ Mn), by CHO Cell Media, 2017–2031
Figure 08: Global Serum-free Media Market Revenue (US$ Mn), by Protein Expression Media, 2017–2031
Figure 09: Global Serum-free Media Market Revenue (US$ Mn), by Immunology Media, 2017–2031
Figure 10: Global Serum-free Media Market Revenue (US$ Mn), by Insect Cell Media, 2017–2031
Figure 11: Global Serum-free Media Market Revenue (US$ Mn), by Hybridoma Media, 2017–2031
Figure 12: Global Serum-free Media Market Revenue (US$ Mn), by Stem Cell Media, 2017–2031
Figure 13: Global Serum-free Media Market Revenue (US$ Mn), by chemically defined Media, 2017–2031
Figure 14: Global Serum-free Media Market Attractiveness Analysis, by Media Type, 2021–2031
Figure 15: Global Serum-free Media Market Value Share Analysis, by End-user, 2020 and 2031
Figure 16: Global Serum-free Media Market Revenue (US$ Mn), by Biopharma Industry, 2017–2031
Figure 17: Global Serum-free Media Market Revenue (US$ Mn), by Clinical Research Organizations, 2017–2031
Figure 18: Global Serum-free Media Market Revenue (US$ Mn), by Research Centers, 2017–2031
Figure 19: Global Serum-free Media Market Revenue (US$ Mn), by Others, 2017–2031
Figure 20: Global Serum-free Media Market Attractiveness Analysis, by End-user, 2021–2031
Figure 21: Global Serum-free Media Market Value Share Analysis, by Region, 2020 and 2031
Figure 22: Global Serum-free Media Market Analysis, by Region
Figure 23: North America Serum-free Media Market Value (US$ Mn) Forecast 2017–2031
Figure 24: North America Serum-free Media Market Value Share (%), by Country, 2020 and 2031
Figure 25: North America Serum-free Media Market Attractiveness Analysis, by Country, 2021–2031
Figure 26: North America Serum-free Media Market Value Share Analysis, by Media Type, 2020 and 2031
Figure 27: North America Serum-free Media Market Attractiveness Analysis, by Media Type, 2021–2031
Figure 28: North America Serum-free Media Market Value Share Analysis, by End-user, 2020 and 2031
Figure 29: North America Serum-free Media Market Attractiveness Analysis, by End-user, 2021–2031
Figure 30: Europe Serum-free Media Market Value (US$ Mn) Forecast 2017–2031
Figure 31: Europe Serum-free Media Market Value Share (%), by Country/Sub-region, 2020 and 2031
Figure 32: Europe Serum-free Media Market Attractiveness Analysis, by Country/Sub-region, 2021–2031
Figure 33: Europe Serum-free Media Market Value Share Analysis, by Media Type, 2020 and 2031
Figure 34: Europe Serum-free Media Market Attractiveness Analysis, by Media Type, 2021–2031
Figure 35: Europe Serum-free Media Market Value Share Analysis, by End-user, 2020 and 2031
Figure 36: Europe Serum-free Media Market Attractiveness Analysis, by End-user, 2021–2031
Figure 37: Asia Pacific Serum-free Media Market Value (US$ Mn) Forecast 2017–2031
Figure 38: Asia Pacific Serum-free Media Market Value Share (%), by Country/Sub-region, 2020 and 2031
Figure 39: Asia Pacific Serum-free Media Market Attractiveness Analysis, by Country/Sub-region, 2021–2031
Figure 40: Asia Pacific Serum-free Media Market Value Share Analysis, by Media Type, 2020 and 2031
Figure 41: Asia Pacific Serum-free Media Market Attractiveness Analysis, by Media Type, 2021–2031
Figure 42: Asia Pacific Serum-free Media Market Value Share Analysis, by End-user, 2020 and 2031
Figure 43: Asia Pacific Serum-free Media Market Attractiveness Analysis, by End-user, 2021–2031
Figure 44: Latin America Serum-free Media Market Value (US$ Mn) Forecast 2017–2031
Figure 45: Latin America Serum-free Media Market Value Share (%), by Country/Sub-region, 2020 and 2031
Figure 46: Latin America Serum-free Media Market Attractiveness Analysis, by Country/Sub-region, 2021–2031
Figure 47: Latin America Serum-free Media Market Value Share Analysis, by Media Type, 2020 and 2031
Figure 48: Latin America Serum-free Media Market Attractiveness Analysis, by Media Type, 2021–2031
Figure 49: Latin America Serum-free Media Market Value Share Analysis, by End-user, 2020 and 2031
Figure 50: Latin America Serum-free Media Market Attractiveness Analysis, by End-user, 2021–2031
Figure 51: Middle East & Africa Serum-free Media Market Value (US$ Mn) Forecast 2017–2031
Figure 52: Middle East & Africa Serum-free Media Market Value Share (%), by Country/Sub-region, 2020 and 2031
Figure 53: Middle East & Africa Serum-free Media Market Attractiveness Analysis, by Country/Sub-region, 2021–2031
Figure 54: Middle East & Africa Serum-free Media Market Value Share Analysis, by Media Type, 2020 and 2031
Figure 55: Middle East & Africa Serum-free Media Market Attractiveness Analysis, by Media Type, 2021–2031
Figure 56: Middle East & Africa Serum-free Media Market Value Share Analysis, by End-user, 2020 and 2031
Figure 57: Middle East & Africa Serum-free Media Market Attractiveness Analysis, by End-user, 2021–2031
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Serum-free Media Market Insights, 2021-2031
