Neonatal Respiratory Distress Syndrome Market

Neonatal Respiratory Distress Syndrome Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2020 - 2030

Close Monitoring of COVID Positive Neonates in ICUs Reduces Production Stress

The screening of all new infants at high risk of exposure to COVID-19 (coronavirus) is a fast growing phenomenon in healthcare facilities. This is being carried out based on their family history. Companies in the neonatal respiratory disease syndrome market are boosting their production output to meet the demanding needs of clinicians. Manufacturers are educating healthcare professionals to isolate all high-risk neonates in intensive care units (ICUs) to contain the spread of COVID-19 and reduce production stress on pharma companies. As such, the nucleic acid test is being recommended for high-risk neonates.

Neonates are prone to rapidly developing respiratory distress and multiple organ failure. Hence, companies in the neonatal respiratory disease syndrome market are increasing awareness about admitting COVID positive infants in ICUs to enable close monitoring. This is necessary since a second wave of coronavirus is prevalent in the U.S., India, and European countries.

Acute Complications in Infants Inhibit Market Growth

Due to an alarmingly high prevalence of neonatal respiratory disease syndrome worldwide, pharma companies are increasing their production capacities to manufacture antenatal corticosteroids, oxygenation, and ventilation equipment. However, healthcare companies need to address issues of complications after the acute course of respiratory disease syndrome. Acute complications such as air-leak syndromes and pulmonary interstitial emphysema are creating hurdles for companies in the neonatal respiratory disease syndrome market. Companies should increase their focus in laboratory workup and imaging technologies to improve medical outcomes in hospitals and clinics.

The increased coordination among numerous care teams such as respiratory therapists, physicians, and pharmacists is highly recommended to improve clinical numbers. Companies in the neonatal respiratory disease syndrome market are increasing awareness within healthcare commissions for high level of clinical expertise in healthcare settings.

Surfactant Replacement Combined with Mechanical Ventilation Improves Lung Oxygenation

Mechanical ventilation facilitates adequate respiratory support while balancing the risks of oxygen toxicity, barotrauma, and volutrauma. However, this treatment also makes them susceptible to bronchopulmonary dysplasia (BPD) and other chronic lung diseases. Hence, companies in the neonatal respiratory disease syndrome market are increasing the availability of surfactant replacement treatment to improve medical outcomes. Surfactant replacement is gaining popularity as the go-to therapy for reducing the rate of morbidity and mortality, especially in countries with large pockets of poverty.

Companies in the neonatal respiratory disease syndrome market are increasing their R&D activities to determine the best dose, timing, and methods for the delivery of surfactant treatment. This helps to maximize the effects and minimize risks of bronchopulmonary dysplasia in neonates. It has been found that early treatment, with the help of pulmonary surfactant and mechanical ventilation, could remarkably improve lung oxygenation and compliance.

Targeted Treatments and Less Invasive Options Reduce Incidence of BPD in Infants

Apart from surfactant replacement and mechanical ventilation, manufacturers in the neonatal respiratory disease syndrome market are increasing the availability of inhaled nitric oxide treatment. This treatment is becoming a mainstay for neonatal respiratory disease syndrome, owing to its advantage of improving oxygenation and reduce pulmonary inflammation. Treatment measures taken within 12 hrs of birth are being highly recommended by healthcare commissions, since it relieves infants from acute symptoms. The reduction in chronic lung diseases later in life is being achieved in individuals with the help of inhaled nitric oxide treatment.

Targeted treatments and less invasive options for infants are bolstering the credibility credentials of companies in the neonatal respiratory disease syndrome market.These companies are spreading awareness about selective use of surfactants rather than prophylactic use to reduce incidences of bronchopulmonary dysplasia in neonates.

Focus on Nutrition Helps Increase Survival Time of Preterm Neonates

Companies in the neonatal respiratory disease syndrome market are making propositions to administer surfactant differently with the help of catheters. Surfactant treatment is being combined with continuous positive airway pressure (CPAP) to eliminate the need of mechanical ventilation. On the other hand, manufacturers in the neonatal respiratory disease syndrome market are increasing their production capabilities in nebulized surfactant to reduce the need for intubation in preterm infants treated with nasal CPAP. Pharma companies are in discussions with researchers to revise protocols on mechanical oxygenation and ventilation.

The administration of vitamin D in infants is found to stimulate lung maturation. Pharma companies are capitalizing on this opportunity, as vitamin D deficiency leads to fall in oxygen levels and reduces survival time of preterm neonates. As such, vitamin A administration is contributing toward cell growth and decline in BPD rates.

Neonatal respiratory distress syndrome, also referred to as infant respiratory distress syndrome is characterized by a particular condition often observed in premature babies, usually born about six weeks before their due dates. During this condition, lungs of the premature infants lose the ability to produce enough surfactants in order to provide oxygen to the body. Surfactants are liquids made up of fat and proteins and it helps the lungs to remain inflated so that infants can breathe in and out immediately after their birth. Hence, the prime cause for the prevalence of neonatal respiratory distress syndrome is the lack of surfactant in the lungs. Various signs and symptoms associated with neonatal respiratory distress syndrome are as follows:
  • Grunting respiration
  • Flaring nostrils
  • Cyanosis
  • Blue-colored lips, fingers and toes
  • Sharp pulling in the chest

Rapid breathing
Based on the treatments and mediations, the neonatal respiratory distress syndrome market can be segmented as follows:

  • Surfactant Replacement Therapy: The infants who suffer from respiratory distress syndrome are given surfactant through a breathing tube. Surfactants are administered until the lungs start to make the substance on their own.
  • Oxygen Therapy: Infants with severe breathing problems are given oxygen therapy through a ventilator or NCPAP machine, i.e., nasal continuous positive airway pressure. This therapy ensures that there is a sufficient supply of oxygen to the infant in order to breathe effectively.
  • Supportive Therapy: Supportive therapy helps the premature infants to meet their basic needs of nutrition and protection. For instance, use of incubator to keep the baby warm, and fluids and nutrients intake through needles inserted into the needle’s veins.
  • Other treatments: Other treatments include drugs and therapeutics to cure neonatal respiratory distress syndrome. Example, surfaxin (lucinactant), which was approved in March, 2012 by the U.S. Food and Drug Administration for the treatment of infant respiratory distress syndrome.
    Based on geography, the neonatal respiratory distress market can be segmented into four major regions: North America, Europe, Asia Pacific and Rest of the World. Out of these regions, North America dominates the neonatal respiratory distress market followed by Europe. The prime reasons which have driven the growth of this market in these regions are high prevalence of respiratory disorders in infants and increasing genetic problems with lung development. According to a survey, neonatal respiratory distress syndrome is estimated to affect around 20,000-30,000 infants each year in the United States. Asia Pacific is the most promising market for the growth of neonatal respiratory distress syndrome market as there are many developing regions that are growing at a steady pace. The major factors which will propel the growth of this market in Asia Pacific are high birth rate, increasing awareness related to the complications of respiratory distress syndrome in infants and increasing pregnancy-induced hypertension due to malnutrition. Moreover, increasing incidences of premature labor and high-risk pregnancy in mothers would drive the Asian market towards future growth.
    Many pharmaceutical companies and clinical trial institutes are constantly trying to come up with novel therapeutic development for the treatment of neonatal respiratory distress syndrome. Some of the leading players operating in the neonatal respiratory distress market are Chiesi Farmaceutici SpA, Discovery Laboratories, Inc., Takeda Pharmaceutical Company Limited, Auckland City Hospital, Menzies Research Institute and many others.

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