Hepatorenal Syndrome Treatment Market

Hepatorenal Syndrome Treatment Market (Type: Type 1 Hepatorenal Syndrome, Type 2 Hepatorenal Syndrome; Treatment: Therapeutics, Surgical Treatment; End User: Hospitals & Clinics, Ambulatory Surgical Centers, Academic & Research Institutes, and Others) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2019 - 2027

Exponential Growth in Therapeutics Boosts Growth of Hepatorenal Syndrome Treatment Market

Improvements in the therapeutics landscape of the hepatorenal syndrome treatment market are creating new avenues in incremental opportunities for healthcare companies. Although surgical treatments dominate the hepatorenal syndrome (HRS) treatment market, analysts at Transparency Market Research (TMR) anticipate an exponential growth for therapeutics in terms of market value share. Therapeutics are projected to rise from a market value share of ~1% in 2018 to ~6% by the end of 2027, in the hepatorenal syndrome treatment market. Thus, lucrative opportunities in the therapeutics landscape are attracting the attention of healthcare companies.

Healthcare companies are developing improved formulations of therapeutic drugs that are safe and effective for HRS patients. For instance, in May 2019, Mallinckrodt - a global specialty pharmaceutical company, announced the launch of Terlipressin - an investigational agent for the treatment of type 1 hepatorenal syndrome.

Since there are no treatments approved in the U.S. and Canada for HRS-1, healthcare companies are increasing their research efforts to reach full potential in terms of the enrollment of participants. Thus, active enrollment of participants in clinical studies will help enhance the credibility of research outcomes in the hepatorenal syndrome treatment market.

hepatorenal syndrome treatment market infographic

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Health Commissions Recommend Albumin as Cost-effective Treatment Option for Cirrhosis and HRS

Complications of cirrhosis lead to HRS and progressive kidney failure amongst patients with severe liver damage. Hence, healthcare providers prescribe albumin to cirrhotic patients with acute decompensation. Albumin is gaining increased popularity in the hepatorenal syndrome treatment market, since it serves as a cost-effective treatment option for HRS and cirrhosis. As such, there is growing demand for albumin in hospitals and ambulatory surgical centers across Germany, Italy, and Spain.

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Healthcare companies in the hepatorenal syndrome treatment market are increasing their production capabilities of albumin, since the protein serves as a low-cost and effective alternative to saline, gelatin, and no fluid treatment of large volume paracentesis (LVP). It is found that, the combination of albumin with antibiotics is clinically more effective than antibiotics alone in the hepatorenal syndrome treatment landscape. To reduce the severe complications of cirrhosis amongst HRS patients, healthcare companies in the hepatorenal syndrome treatment market are increasing awareness about the combination therapy of albumin with vasoconstrictors.

Albumin is being increasingly used in combination with other drugs such as terlipressin. This trend is gaining increased popularity due to its low medical complication costs. Due to reduced rates of renal impairment and reduced mortality rates, health commissions across various countries are recommending the prescription of albumin to treat serious conditions of HRS.

Economic Evaluation Helps Companies Analyze Cost Difference for HRS Treatment Options

HRS is characterized by renal failure in patients suffering from advanced chronic liver disease (CLD). This disease condition has led to increased hospitalizations in the U.S. As such, the U.S. currently accounts for the highest revenue amongst all regions in the hepatorenal syndrome treatment market, with a value recorded at ~US$ 5 billion in 2018. Therefore, companies in the hepatorenal syndrome treatment market are increasing their efforts to introduce advanced treatment options for HRS patients in the U.S. However, it is found that, there is a growing need for cost-efficient treatment alternatives for the diagnosis of HRS in the U.S. Costly HRS treatments have created the problem of economic burden amongst patients. This has adversely affected the credibility of outcomes, as patients lack access to cost-efficient and effective treatment options.

Hence, companies in the hepatorenal syndrome treatment market are carrying out extensive research to analyze the number of hospitals that offer treatments at a higher cost. This is particularly compared with hospitals in the developing countries of Asia Pacific. For instance, it has been found that, the cost of treatment for HRS is less expensive in India as compared to the economic evaluation of treatment offered in Brazil. Companies in the hepatorenal syndrome treatment market are increasing research & development to devise strategies that reduce the economic burden on patients, and are increasing the availability of effective treatment options at U.S. hospitals.

hepatorenal syndrome treatment market segmentation
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Analysts’ Viewpoint

In 2027, surgical treatments are projected to account for ~94% market share of the hepatorenal syndrome treatment market. Hence, healthcare companies should focus on the application of evidence-based algorithms, catering to surgical and pharmacological options for patients suffering from HRS.

However, surgical repair of umbilical hernia in cirrhotic patients has increased risks of high postoperative morbidity and mortality. To overcome this hurdle, companies should aid healthcare providers to increase their efficacy in elective surgery with perioperative preparations to ensure effective and safe outcomes after a surgery. Since HRS treatment is less expensive in Asia Pacific, healthcare companies should capitalize on this opportunity, as the region is estimated for exponential market growth amongst all the other regions in the landscape.

Global Hepatorenal Syndrome Treatment Market: Overview

  • The global hepatorenal syndrome treatment market was valued at ~US$ 11 Bn in 2018 and is projected to reach a value of ~US$ 16.7 Bn by 2027, expanding at a CAGR of ~5% from 2019 to 2027.
  • North America, Europe, and Asia Pacific were the major regional hepatorenal syndrome treatment markets in 2018. The hepatorenal syndrome treatment markets in North America and Asia Pacific are likely to expand at CAGRs of 5.1% and 4.8%, respectively, during the forecast period.
  • The global hepatorenal syndrome treatment market is projected to witness high growth, owing to promising effective therapies in the pipeline for addressing gaps in the treatment of hepatorenal syndrome.
  • Increase in the prevalence and incidence of hepatorenal syndrome and development and launch of various pipeline drugs for the treatment of hepatorenal syndrome in the near future are expected to drive the global HRS treatment market during the forecast period.

Global Hepatorenal Syndrome Treatment Market: Significant Growth Prospects in Developing Countries

  • Developing economies in Asia Pacific, Latin America, and Eastern Europe hold great opportunities for the hepatorenal syndrome treatment market, owing to their increasing population, coupled with rise in health care-related customer expenditure brought about by the rise in their economies.
  • Continuous technological advancements in surgical procedures for liver and kidney diseases with respect to higher efficacy and targeted therapeutic role have widened the scope for players present in the hepatorenal syndrome treatment market.
  • New drugs with combined features of reduced side-effects and higher efficacy have a significant potential for growth in the hepatorenal syndrome treatment market. Thus, the introduction of new products can help new entrants establish their foothold in the hepatorenal syndrome treatment market.

Increase in Disease Awareness & Patient Support Programs to Boost Hepatorenal Syndrome Treatment Market

  • In order to reduce mortality and morbidity rates, governments in developed and developing countries are conducting awareness campaigns to encourage people to go for the early diagnosis of kidney and liver diseases. This, in turn, is expected to increase awareness regarding hepatorenal syndrome diagnosis and treatment, thereby boosting the growth of the global hepatorenal syndrome treatment market.
  • For instance, every 2nd Thursday of March is observed as World Kidney Day. It is a global awareness campaign to increase awareness about chronic kidney diseases and the introduction of healthy changes in life to reduce risk factors.
  • Moreover, in developing countries such as India, hospitals are raising awareness about these diseases. For instance, in February 2016, Noida-based Jaypee Hospital in India organized a kidney and liver disease awareness campaign.

Global Hepatorenal Syndrome Treatment Market: Fast Track and Orphan Drug Designations

  • In 1983, recognizing that adequate drugs for rare disorders had not been developed in the U.S., the Congress passed the Orphan Drug Act to provide incentives to induce companies to develop drugs for THE treatment of rare and neglected diseases. Orphan drug status is granted to drugs and biologics that are intended for the diagnosis, prevention, or treatment of rare diseases or disorders that affect fewer than 200,000 people in the U.S. Orphan drugs are given priority review, allowing them to be assessed within six months for approval.
  • Hepatorenal syndrome is a form of impaired kidney function that occurs in individuals with advanced chronic liver disease. AROUND 40% of people with ascites and cirrhosis develop hepatorenal syndrome.
  • In case of hepatorenal syndrome treatment, several drugs have received orphan drug designation, thereby accelerating their approval process, and this can act as a factor pushing the growth of the hepatorenal syndrome treatment market.
  • For instance, in November 2004, ESP Pharma, Inc. announced that FDA had granted Orphan Drug Designation to Terlipressin for the treatment of hepatorenal syndrome Type 1, providing seven years marketing exclusivity upon the completion of clinical studies and FDA approval of the drug for this indication.
  • Additionally, in November 2018, BioVie Inc. announced that the FDA has granted Orphan Drug designation to its Terlipressin drug for the treatment of hepatorenal syndrome (HRS).
  • The designation for orphan drug allows manufacturers to qualify for various incentives, including tax credits for qualified clinical trials, along with seven years of market exclusivity upon regulatory approval. This is likely to drive the hepatorenal syndrome treatment market during the forecast period.

Global Hepatorenal Syndrome Treatment Market: Competition Landscape

  • Strategic collaborations among key manufacturers and companies having their products in clinical trials to expedite the process of research & development are likely to help thousands of patients suffering from hepatorenal syndrome. Rise in the trend of collaborations is projected to drive the hepatorenal syndrome treatment market by fueling novel product launches.
  • In 2010, Ikaria, Inc. entered into a strategic collaboration with Orphan Therapeutics to acquire the rights of Orphan Therapeutics’ drug ‘LUCASSIN’ in North America and Australia. Ikaria, Inc. holds all the necessary rights to manufacture, develop, and commercialize LUCASSIN in Mexico, the U.S., and Australia.
  • Additionally, in April 2017, Mallinckrodt plc acquired Ikaria, Inc. The deal was valued at US$ 2.3 Bn.
  • Such collaborations are likely to enhance the chances of the development of comprehensive treatment for hepatorenal syndrome, thereby improving the survival rate of patients, and eventually surging the growth of the hepatorenal syndrome treatment market.

Hepatorenal Syndrome Treatment Market - Segmentation

In order to understand the granular and broader nuances of the market, the segmentation of the hepatorenal syndrome treatment market has been done on the basis of type, treatment, end user, and region. This is one way by which incremental opportunities can be assessed in the hepatorenal syndrome treatment market.

Type

  • Type 1
  • Hepatorenal
  • Syndrome
  • Type 2
  • Hepatorenal
  • Syndrome

Treatment

  • Therapeutics
    • Terlivaz
    • Glypressin
    • Lucassin
    • Hepatoren
  • Surgical Treatment
    • Liver Transplantation
    • Surgical Shunting
    • Renal Replacement Therapy
    • Others

End User

  • Hospitals &
  • Clinics
  • Ambulatory
  • Surgical
  • Centers
  • Academic &
  • Research
  • Institutes
  • Others

Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

Frequently Asked Questions

What is the total market worth of hepatorenal syndrome treatment market?

Hepatorenal syndrome treatment market to reach a valuation of ~US$ 16.7 Bn by 2027

What is the anticipated CAGR of the hepatorenal syndrome treatment market in the forecast period?

Hepatorenal syndrome treatment market is projected to expand at a CAGR of ~5% from 2019 to 2027

What are the key driving factors for the growth of the hepatorenal syndrome treatment market?

Hepatorenal syndrome treatment market is driven by an increase in the awareness and acceptance of hepatorenal syndrome treatment

Which region is expected to project the highest market share in the global hepatorenal syndrome treatment market?

North America accounted for a major share of the global hepatorenal syndrome treatment market

Who are the key players in the global hepatorenal syndrome treatment market?

Key players in the global hepatorenal syndrome treatment market include Cumberland Pharmaceuticals, Inc., Orphan Therapeutics, LLC, BioVie Inc., and Mallinckrodt Pharmaceuticals.

    1. Preface 

        1.1. Report Scope and Market Segmentation 

        1.2. Research Highlights

    2. Assumptions and Research Methodology 

        2.1. Assumptions and Acronyms Used

        2.2. Research Methodology

    3. Executive Summary

        3.1. Global Hepatorenal Syndrome Treatment Market: Market Snapshot

    4. Market Overview

        4.1. Global Hepatorenal Syndrome Treatment Market: Type Overview 

        4.2. Global Hepatorenal Syndrome Treatment Market: Key Industry Developments

        4.3. Market Dynamics

        4.4. Drivers and Restraints Snapshot Analysis

        4.5. Drivers

            4.5.1. Fast track and orphan drug designations

            4.5.2. Increase in strategic collaboration among key players

        4.6. Restraints

            4.6.1. Side-effects and risks related to drug usage

            4.6.2. Stringent regulatory requirements

        4.7. Opportunities

        4.8. Global Hepatorenal Syndrome Treatment Market Revenue Projections (US$ Mn), 2017–2027

    5. Key Insights

        5.1. Pipeline Analysis

        5.2. Regulatory Scenario by Region/Country

        5.3. Key Industry Events (Mergers, Acquisitions, Collaborations, Launch & Approvals, etc)

        5.4. Prevalence of Liver & Kidney Diseases by Region/Globally

    6. Global Hepatorenal Syndrome Treatment Market Analysis, by Type

        6.1. Introduction

        6.2. Global Hepatorenal Syndrome Treatment Market Value and Forecast, by Type

            6.2.1. Type 1 Hepatorenal Syndrome

            6.2.2. Type 2 Hepatorenal Syndrome

        6.3. Global Hepatorenal Syndrome Treatment Market Analysis, by Type

        6.4. Global Hepatorenal Syndrome Treatment Market Attractiveness Analysis, by Type

    7. Global Hepatorenal Syndrome Treatment Market Analysis, by Treatment

        7.1. Introduction

        7.2. Global Hepatorenal Syndrome Treatment Market Value and Forecast, by Treatment

            7.2.1. Therapeutics

                7.2.1.1. Terlivaz

                7.2.1.2. Glypressin

                7.2.1.3. Lucassin 

                7.2.1.4. Hepatoren

            7.2.2. Surgical Treatment

                7.2.2.1. Liver Transplantation

                7.2.2.2. Surgical Shunting

                    7.2.2.2.1. Peritoneovenous Shunting

                    7.2.2.2.2. Transjugular Intrahepatic Portosystemic Shunt (TIPS)

                    7.2.2.2.3. Others

                7.2.2.3. Renal Replacement Therapy

                7.2.2.4. Others

        7.3. Global Hepatorenal Syndrome Treatment Market Analysis, by Treatment

        7.4. Global Hepatorenal Syndrome Treatment Market Attractiveness Analysis, by Treatment

    8. Global Hepatorenal Syndrome Treatment Market Analysis, by End-user

        8.1. Introduction

        8.2. Global Hepatorenal Syndrome Treatment Market Value and Forecast, by End-user

            8.2.1. Hospitals & Clinics

            8.2.2. Ambulatory Surgical Centers

            8.2.3. Academic & Research Institutes

            8.2.4. Others

        8.3. Global Hepatorenal Syndrome Treatment Market Analysis, by End-user

        8.4. Global Hepatorenal Syndrome Treatment Market Attractiveness Analysis, by End-user

    9. Global Hepatorenal Syndrome Treatment Market Analysis, by Region

        9.1. Global Hepatorenal Syndrome Treatment Market Value and Forecast, by Region, 2017–2027 

            9.1.1. North America

            9.1.2. Europe

            9.1.3. Asia Pacific

            9.1.4. Latin America

            9.1.5. Middle East & Africa

        9.2. Global Hepatorenal Syndrome Treatment Market Analysis, by Region

        9.3. Global Hepatorenal Syndrome Treatment Market Attractiveness Analysis, by Region

    10. North America Hepatorenal Syndrome Treatment Market Analysis

        10.1. North America Hepatorenal Syndrome Treatment Market 

        10.2. North America Hepatorenal Syndrome Treatment Market Overview

        10.3. North America Hepatorenal Syndrome Treatment Market Value and Forecast, by Type

            10.3.1. Type 1 Hepatorenal Syndrome

            10.3.2. Type 2 Hepatorenal Syndrome

        10.4. North America Hepatorenal Syndrome Treatment Market Value and Forecast, by Treatment

            10.4.1. Therapeutics

                10.4.1.1. Terlivaz

                10.4.1.2. Glypressin

                10.4.1.3. Lucassin 

                10.4.1.4. Hepatoren

            10.4.2. Surgical Treatment

                10.4.2.1. Liver Transplantation

                10.4.2.2. Surgical Shunting

                    10.4.2.2.1. Peritoneovenous Shunting

                    10.4.2.2.2. Transjugular Intrahepatic Portosystemic Shunt (TIPS)

                    10.4.2.2.3. Others

                10.4.2.3. Renal Replacement Therapy

            10.4.3. Others

        10.5. North America Hepatorenal Syndrome Treatment Market Value and Forecast, by End-user

            10.5.1. Hospitals & Clinics

            10.5.2. Ambulatory Surgical Centers

            10.5.3. Academic & Research Institutes

            10.5.4. Others

        10.6. North America Hepatorenal Syndrome Treatment Market Forecast, by Country

            10.6.1. U.S.

            10.6.2. Canada

        10.7. North America Hepatorenal Syndrome Treatment Market Attractiveness Analysis 

            10.7.1. By Type

            10.7.2. By Treatment

            10.7.3. By End-user

            10.7.4. By Country

    11. Europe Hepatorenal Syndrome Treatment Market Analysis

        11.1. Europe Hepatorenal Syndrome Treatment Market 

        11.2. Europe Hepatorenal Syndrome Treatment Market Overview

        11.3. Europe Hepatorenal Syndrome Treatment Market Value and Forecast, by Type

            11.3.1. Type 1 Hepatorenal Syndrome

            11.3.2. Type 2 Hepatorenal Syndrome

        11.4. Europe Hepatorenal Syndrome Treatment Market Value and Forecast, by Treatment

            11.4.1. Therapeutics

                11.4.1.1. Terlivaz

                11.4.1.2. Glypressin

                11.4.1.3. Lucassin 

                11.4.1.4. Hepatoren

            11.4.2. Surgical Treatment

                11.4.2.1. Liver Transplantation

                11.4.2.2. Surgical Shunting

                    11.4.2.2.1. Peritoneovenous Shunting

                    11.4.2.2.2. Transjugular Intrahepatic Portosystemic Shunt (TIPS)

                    11.4.2.2.3. Others

                11.4.2.3. Renal Replacement Therapy

            11.4.3. Others

        11.5. Europe Hepatorenal Syndrome Treatment Market Value and Forecast, by End-user

            11.5.1. Hospitals & Clinics

            11.5.2. Ambulatory Surgical Centers

            11.5.3. Academic & Research Institutes

            11.5.4. Others

        11.6. Europe Hepatorenal Syndrome Treatment Market Forecast, by Country/Sub-region

            11.6.1. U.K.

            11.6.2. France

            11.6.3. Germany

            11.6.4. Spain

            11.6.5. Italy

            11.6.6. Rest of Europe

        11.7. Europe Hepatorenal Syndrome Treatment Market Attractiveness Analysis 

            11.7.1. By Type

            11.7.2. By Treatment

            11.7.3. By End-user

            11.7.4. By Country/Sub-region

    12. Asia Pacific Hepatorenal Syndrome Treatment Market Analysis

        12.1. Asia Pacific Hepatorenal Syndrome Treatment Market Key Findings

        12.2. Asia Pacific Hepatorenal Syndrome Treatment Market Overview

        12.3. Asia Pacific Hepatorenal Syndrome Treatment Market Value and Forecast, by Type

            12.3.1. Type 1 Hepatorenal Syndrome

            12.3.2. Type 2 Hepatorenal Syndrome

        12.4. Asia Pacific Hepatorenal Syndrome Treatment Market Value and Forecast, by Treatment

            12.4.1. Therapeutics

                12.4.1.1. Terlivaz

                12.4.1.2. Glypressin

                12.4.1.3. Lucassin 

                12.4.1.4. Hepatoren

            12.4.2. Surgical Treatment

                12.4.2.1. Liver Transplantation

                12.4.2.2. Surgical Shunting

                    12.4.2.2.1. Peritoneovenous Shunting

                    12.4.2.2.2. Transjugular Intrahepatic Portosystemic Shunt (TIPS)

                    12.4.2.2.3. Others

                12.4.2.3. Renal Replacement Therapy

            12.4.3. Others

        12.5. Asia Pacific Hepatorenal Syndrome Treatment Market Value and Forecast, by End-user

            12.5.1. Hospitals & Clinics

            12.5.2. Ambulatory Surgical Centers

            12.5.3. Academic & Research Institutes

            12.5.4. Others

        12.6. Asia Pacific Hepatorenal Syndrome Treatment Market Forecast, by Country/Sub-region

            12.6.1. China

            12.6.2. India

            12.6.3. Japan

            12.6.4. Australia & New Zealand

            12.6.5. Rest of Asia Pacific

        12.7. Asia Pacific Hepatorenal Syndrome Treatment Market Attractiveness Analysis 

            12.7.1. By Type

            12.7.2. By Treatment

            12.7.3. By End-user

            12.7.4. By Country/Sub-region

    13. Latin America Hepatorenal Syndrome Treatment Market Analysis

        13.1. Latin America Hepatorenal Syndrome Treatment Market Key Findings

        13.2. Latin America Hepatorenal Syndrome Treatment Market Overview

        13.3. Latin America Hepatorenal Syndrome Treatment Market Value and Forecast, by Type

            13.3.1. Type 1 Hepatorenal Syndrome

            13.3.2. Type 2 Hepatorenal Syndrome

        13.4. Latin America Hepatorenal Syndrome Treatment Market Value and Forecast, by Treatment

            13.4.1. Therapeutics

                13.4.1.1. Terlivaz

                13.4.1.2. Glypressin

                13.4.1.3. Lucassin 

                13.4.1.4. Hepatoren

            13.4.2. Surgical Treatment

                13.4.2.1. Liver Transplantation

                13.4.2.2. Surgical Shunting

                    13.4.2.2.1. Peritoneovenous Shunting

                    13.4.2.2.2. Transjugular Intrahepatic Portosystemic Shunt (TIPS)

                    13.4.2.2.3. Others

                13.4.2.3. Renal Replacement Therapy

            13.4.3. Others

        13.5. Latin America Hepatorenal Syndrome Treatment Market Value and Forecast, by End-user

            13.5.1. Hospitals & Clinics

            13.5.2. Ambulatory Surgical Centers

            13.5.3. Academic & Research Institutes

            13.5.4. Others

        13.6. Latin America Hepatorenal Syndrome Treatment Market Forecast, by Country/Sub-region

            13.6.1. Brazil

            13.6.2. Mexico

            13.6.3. Rest of Latin America

        13.7. Latin America Hepatorenal Syndrome Treatment Market Attractiveness Analysis 

            13.7.1. By Type

            13.7.2. By Treatment

            13.7.3. By End-user

            13.7.4. By Country/Sub-region

    14. Middle East & Africa Hepatorenal Syndrome Treatment Market Analysis

        14.1. Middle East & Africa Hepatorenal Syndrome Treatment Market 

        14.2. Middle East & Africa Hepatorenal Syndrome Treatment Market Overview

        14.3. Middle East & Africa Hepatorenal Syndrome Treatment Market Value and Forecast, by Type

            14.3.1. Type 1 Hepatorenal Syndrome

            14.3.2. Type 2 Hepatorenal Syndrome

        14.4. Middle East & Africa Hepatorenal Syndrome Treatment Market Value and Forecast, by Treatment

            14.4.1. Therapeutics

                14.4.1.1. Terlivaz

                14.4.1.2. Glypressin

                14.4.1.3. Lucassin 

                14.4.1.4. Hepatoren

            14.4.2. Surgical Treatment

                14.4.2.1. Liver Transplantation

                14.4.2.2. Surgical Shunting

                    14.4.2.2.1. Peritoneovenous Shunting

                    14.4.2.2.2. Transjugular Intrahepatic Portosystemic Shunt (TIPS)

                    14.4.2.2.3. Others

                14.4.2.3. Renal Replacement Therapy

            14.4.3. Others

        14.5. Middle East & Africa Hepatorenal Syndrome Treatment Market Value and Forecast, by End-user

            14.5.1. Hospitals & Clinics

            14.5.2. Ambulatory Surgical Centers

            14.5.3. Academic & Research Institutes

            14.5.4. Others

        14.6. Middle East & Africa Hepatorenal Syndrome Treatment Market Forecast, by Country/Sub-region

            14.6.1. GCC Countries

            14.6.2. South Africa

            14.6.3. Rest of Middle East & Africa

        14.7. Middle East & Africa Hepatorenal Syndrome Treatment Market Attractiveness Analysis 

            14.7.1. By Type

            14.7.2. By Treatment

            14.7.3. By End-user

            14.7.4. By Country/Sub-region

    15. Competitive Landscape 

        15.1. Company Profiles

            15.1.1. Cumberland Pharmaceuticals, Inc.

                15.1.1.1. Overview (HQ, Employee Strength, Business Segments)

                15.1.1.2. Financials

                15.1.1.3. Recent Developments

                15.1.1.4. Strategy

            15.1.2. Orphan Therapeutics, LLC. 

                15.1.2.1. Overview (HQ, Employee Strength, Business Segments)

                15.1.2.2. Financials

                15.1.2.3. Recent Developments

                15.1.2.4. Strategy

            15.1.3. BioVie Inc.

                15.1.3.1. Overview (HQ, Employee Strength, Business Segments)

                15.1.3.2. Financials

                15.1.3.3. Recent Developments

                15.1.3.4. Strategy

            15.1.4. Mallinckrodt Pharmaceuticals 

                15.1.4.1. Overview (HQ, Employee Strength, Business Segments)

                15.1.4.2. Financials

                15.1.4.3. Recent Developments

                15.1.4.4. Strategy

    List of Tables

    TABLE 1 Global Hepatorenal Syndrome Treatment Pipeline Analysis (1/5)

    TABLE 2 Global Hepatorenal Syndrome Treatment Pipeline Analysis (2/5)

    TABLE 3 Global Hepatorenal Syndrome Treatment Pipeline Analysis (3/5)

    TABLE 4 Global Hepatorenal Syndrome Treatment Pipeline Analysis (4/5)

    TABLE 5 Global Hepatorenal Syndrome Treatment Pipeline Analysis (5/5)

    TABLE 6 Comparative Analysis of Orphan Drug Policies

    TABLE 7 Worldwide Epidemiology of Liver Diseases 

    TABLE 8 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Type, 2017–2027

    TABLE 9 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Treatment, 2017–2027

    TABLE 10 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Therapeutics, 2017–2027

    TABLE 11 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Treatment, 2017–2027

    TABLE 12 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Shunting, 2017–2027

    TABLE 13 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by End-user, 2017–2027

    TABLE 14 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Region, 2017–2027

    TABLE 15 North America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Country, 2017–2027

    TABLE 16 North America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Type, 2017–2027

    TABLE 17 North America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Treatment, 2017–2027

    TABLE 18 North America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Therapeutics, 2017–2027

    TABLE 19 North America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Treatment, 2017–2027

    TABLE 20 North America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Shunting, 2017–2027

    TABLE 21 North America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by End-user, 2017–2027

    TABLE 22 Europe Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2027

    TABLE 23 Europe Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Type, 2017–2027

    TABLE 24 Europe Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Treatment, 2017–2027

    TABLE 25 Europe Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Therapeutics, 2017–2027

    TABLE 26 Europe Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Treatment, 2017–2027

    TABLE 27 Europe Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Shunting, 2017–2027

    TABLE 28 Europe Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by End-user, 2017–2027

    TABLE 29 Asia Pacific Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2027

    TABLE 30 Asia Pacific Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Type, 2017–2027

    TABLE 31 Asia Pacific Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Treatment, 2017–2027

    TABLE 32 Asia Pacific Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Therapeutics, 2017–2027

    TABLE 33 Asia Pacific Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Treatment, 2017–2027

    TABLE 34 Asia Pacific Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Shunting, 2017–2027

    TABLE 35 Asia Pacific Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by End-user, 2017–2027

    TABLE 36 Latin America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2027

    TABLE 37 Latin America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Type, 2017–2027

    TABLE 38 Latin America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Treatment, 2017–2027

    TABLE 39 Latin America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Therapeutics, 2017–2027

    TABLE 40 Latin America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Treatment, 2017–2027

    TABLE 41 Latin America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Shunting, 2017–2027

    TABLE 42 Latin America Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by End-user, 2017–2027

    TABLE 43 Middle East & Africa Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2027

    TABLE 44 Middle East & Africa Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Type, 2017–2027

    TABLE 45 Middle East & Africa Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Treatment, 2017–2027

    TABLE 46 Middle East & Africa Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Therapeutics, 2017–2027

    TABLE 47 Middle East & Africa Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Treatment, 2017–2027

    TABLE 48 Middle East & Africa Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by Surgical Shunting, 2017–2027

    TABLE 49 Middle East & Africa Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, by End-user, 2017–2027

    List of Figures

    FIG. 1 Global Hepatorenal Syndrome Treatment Market Value (US$ Mn) Forecast, 2017–2027

    FIG. 2 Global Hepatorenal Syndrome Treatment Market Value Share (%), by Type (2018)

    FIG. 3 Global Hepatorenal Syndrome Treatment Market Value Share (%), by Treatment (2018)

    FIG. 4 Global Hepatorenal Syndrome Treatment Market Value Share (%), by End-user (2018)

    FIG. 5 Global Hepatorenal Syndrome Treatment Market Value Share (%), by Region (2018)

    FIG. 6 Regulatory Approval Process - U.S.  

    FIG. 7 Regulatory Approval Process - Europe 

    FIG. 8 Regulatory Approval Process - Japan

    FIG. 9 Regulatory Approval Process - China

    FIG. 10 Revision of Drug Administration Law & Drug Registration Regulation

    FIG. 11 Drug Approval Process in China - Step 1

    FIG. 12 Drug Approval Process in China - Step 2

    FIG. 13 Drug Approval Process in China - Step 3

    FIG. 14 Recent CFDA Regulatory Reforms to Support Innovative Drugs

    FIG. 15 Global Hepatorenal Syndrome Treatment Market Value Share (%), by Type, 2018 and 2027

    FIG. 16 Global Hepatorenal Syndrome Treatment Market Attractiveness, by Type, 2019–2027

    FIG. 17 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Type 1 Hepatorenal Syndrome, 2017–2027

    FIG. 18 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Type 2 Hepatorenal Syndrome, 2017–2027

    FIG. 19 Global Hepatorenal Syndrome Treatment Market Value Share (%), by Treatment, 2018 and 2027

    FIG. 20 Global Hepatorenal Syndrome Treatment Market Attractiveness, by Treatment, 2019–2027

    FIG. 21 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Therapeutics, 2017–2027

    FIG. 22 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Surgical Treatment, 2017–2027

    FIG. 23 Global Hepatorenal Syndrome Treatment Market Value Share (%), by End-user, 2018 and 2027

    FIG. 24 Global Hepatorenal Syndrome Treatment Market Attractiveness, by End-user, 2019–2027

    FIG. 25 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Hospitals & Clinics, 2017–2027

    FIG. 26 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Ambulatory Surgical Centers, 2017–2027

    FIG. 27 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Academic & Research Institutes, 2017–2027

    FIG. 28 Global Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) Forecast and Y-o-Y Growth (%) Projection, by Others, 2017–2027

    FIG. 29 Global Hepatorenal Syndrome Treatment Market Value Share (%), by Region, 2018 and 2027

    FIG. 30 Global Hepatorenal Syndrome Treatment Market Attractiveness, by Region, 2019–2027

    FIG. 31 North America Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, 2017–2027

    FIG. 32 North America Hepatorenal Syndrome Treatment Market Value Share (%), by Country, 2018 and 2027

    FIG. 33 North America Hepatorenal Syndrome Treatment Market Attractiveness, by Country, 2019–2027

    FIG. 34 Europe Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, 2017–2027

    FIG. 35 Europe Hepatorenal Syndrome Treatment Market Value Share (%), by Country/Sub-region, 2018 and 2027

    FIG. 36 Europe Hepatorenal Syndrome Treatment Market Attractiveness, by Country/Sub-region, 2019–2027

    FIG. 37 Asia Pacific Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, 2017–2027

    FIG. 38 Asia Pacific Hepatorenal Syndrome Treatment Market Value Share (%), by Country/Sub-region, 2018 and 2027

    FIG. 39 Asia Pacific Hepatorenal Syndrome Treatment Market Attractiveness, by Country/Sub-region, 2019–2027

    FIG. 40 Latin America Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, 2017–2027

    FIG. 41 Latin America Hepatorenal Syndrome Treatment Market Value Share (%), by Country/Sub-region, 2018 and 2027

    FIG. 42 Latin America Hepatorenal Syndrome Treatment Market Attractiveness, by Country/Sub-region, 2019–2027

    FIG. 43 Middle East & Africa Hepatorenal Syndrome Treatment Market Revenue (US$ Mn) and Y-o-Y Growth (%) Forecast, 2017–2027

    FIG. 44 Middle East & Africa Hepatorenal Syndrome Treatment Market Value Share (%), by Country/Sub-region, 2018 and 2027

    FIG. 45 Middle East & Africa Hepatorenal Syndrome Treatment Market Attractiveness, by Country/Sub-region, 2019–2027

    FIG. 46 Cumberland Pharmaceuticals, Inc., Revenue (US$ Mn) and Y-o-Y Growth (%), 2014–2018

    FIG. 47 Cumberland Pharmaceuticals, Inc., Breakdown of Net Sales, by Region, 2018

    FIG. 48 Mallinckrodt Pharmaceuticals, Revenue (US$ Mn) and Y-o-Y Growth (%), 2015–2018

    FIG. 49 Mallinckrodt Pharmaceuticals, R&D Expenses, 2015–2018

    FIG. 50 Mallinckrodt Pharmaceuticals, Breakdown of Net Sales, by Region, 2018

    FIG. 51 Mallinckrodt Pharmaceuticals, Breakdown of Net Sales, by Business Segment, 2018

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